The Role of Mitochondrial DNA Damage and Function in Skin Ageing
Time: 10:30 - 11:00
Date: 4 July 2018
Theatre: The Royal Society of Medicine
Oxidative stress is the resultant damage due to redox imbalances and is linked to ageing in many tissues including skin. In ageing skin there are bioenergetic differences between keratinocytes and fibroblasts which provide a potential ageing biomarker. The differences in skin bioenergy are part of the mitochondrial theory of ageing which remains one of the most widely accepted ageing theories describing subsequent increasing free radical generation. Mitochondria are the major source of cellular oxidative stress and form part of the vicious cycle theory of ageing. External and internal sources of oxidative stress include UVR/IR, pollution (environment), lifestyle (exercise and diet), alcohol and smoking all of which may potentially impact on skin. This also links to differences in skin cell types in terms of the UVR action spectrum for nuclear and mitochondrial DNA damage (UVR biomarker in skin). Recent work associates bioenergy production and oxidative stress with pigment production.
- Prof. Mark Birch-Machin Professor of Molecular Dermatology - Newcastle University